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Two other medication to deal with severe constipation attributable to opioid painkillers. Naloxegol is available as oral tablets while methylnaltrexone is just available as an injection.
It helps relieve constipation by pulling water into your bowels, which softens stools. Its unwanted effects embody cramps, diarrhea, extreme or frequent bowel actions, gas, and nausea. The commonest facet impact of Linzess is diarrhea, especially if taken with a excessive fats meal. It also should not be taken by pregnant or nursing women as a result of high doses have been toxic to both the mom and fetus in animal studies.
These drugs stimulate the muscle tissue of the intestines to maneuver the stool along. That fast movement, which may trigger cramping, lessens water absorption and softens the stool. These drugs might help alleviate single episodes of constipation, but they don’t assist improve persistent constipation and aren't really helpful for lengthy-term use . Laxatives are another choice and there are several differing kinds.
In one of many major studies, for example, 70 percent of people taking Amitiza skilled a minimum of one side effect versus 50 percent taking the placebo. About 9 p.c of patients needed to stop taking Amitiza due to unwanted side effects. The drug has also been linked to a feeling of chest tightness and issue breathing.
The prices of Amitiza and Linzess are another draw back. They are each costly brand-name medication costing more than $300 a month , and there have been no research comparing them to more established constipation medicines. If you've chronic constipation, we’d recommend that you just rule out each stool softeners and stimulant laxatives. Unfortunately, very few studies have directly compared the varied constipation medicine with each other. You and your physician’s choice of therapy will depend on the kind of constipation you could have, its length and severity, different medical situations you could have and different medicines you are taking.
Amitiza and Linzess are relatively new medicine that cause the cells that line the intestines to secrete chloride, sodium and water to help soften stools. The FDA approved each to deal with chronic constipation and irritable bowel syndrome where the primary symptom is constipation. The three prescription-solely medicines used to treat constipation are lactulose , linaclotide and lubiprostone . So-referred to as stimulant laxatives embody such medication as senna (sometimes known as the sennosides; Ex-Lax, Senokot, other brands and generics) and bisacodyl .

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